However, its administration presents some drawbacks such as high toxicity and low bioavailability.
Also nowadays, vitamin D is recognized as a potential therapeutic agent in anticancer therapy. Thus, the awareness that vitamin D insufficiency/deficiency may be associated with various diseases has grown.
In addition to the traditional role of calcium homeostasis and bone mineralization, calcitriol, the active metabolite of vitamin D, also displays other metabolic activities as antiproliferative, pro-differentiating, anti-inflammatory, immunomodulatory, and antineoplastic effects.
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